Article
The coxsackievirus 2B protein increases efflux of ions from the endoplasmic reticulum and Golgi, thereby inhibiting protein trafficking through the Golgi.
The Journal of biological chemistry - 19 May 2006
de Jong Arjan S, Visch Henk-Jan, de Mattia Fabrizio, van Dommelen Michiel M, Swarts Herman G, Luyten Tomas, Callewaert Geert, Melchers Willem J, Willems Peter H, van Kuppeveld Frank J
Abstract excerpt
Coxsackievirus infection leads to a rapid reduction of the filling state of the endoplasmic reticulum (ER) and Golgi Ca2+ stores. The coxsackievirus 2B protein, a small membrane protein that localizes to the Golgi and to a lesser extent to the ER, has been proposed to play an important role in this effect by forming membrane-integral pores, thereby increasing the efflux of Ca2+ from the stores. Here, evidence is...
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