Article
Golgi alkalinization by the papillomavirus E5 oncoprotein.
The Journal of cell biology - 24 Jan 2000
Schapiro F, Sparkowski J, Adduci A, Suprynowicz F, Schlegel R, Grinstein S
Abstract excerpt
The E5 oncoprotein of bovine papillomavirus type I is a small, hydrophobic polypeptide localized predominantly in the Golgi complex. E5-mediated transformation is often associated with activation of the PDGF receptor (PDGF-R). However, some E5 mutants fail to induce PDGF-R phosphorylation yet retain transforming activity, suggesting an additional mechanism of action. Since E5 also interacts with the 16-kD...
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