Article
Canonical Wnt/β-catenin signalling is essential for optic cup formation.
PloS one - 1 Jan 2013
Hägglund Anna-Carin, Berghard Anna, Carlsson Leif
Abstract excerpt
A multitude of signalling pathways are involved in the process of forming an eye. Here we demonstrate that β-catenin is essential for eye development as inactivation of β-catenin prior to cellular specification in the optic vesicle caused anophthalmia in mice. By achieving this early and tissue-specific β-catenin inactivation we find that retinal pigment epithelium (RPE) commitment was blocked and eye development...
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