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Article

Chronic low-level expression of HIV-1 Tat promotes a neurodegenerative phenotype with aging.

Scientific reports - 10 Aug 2017

Dickens Alex M, Yoo Seung Wan, Chin Alfred C, Xu Jiadi, Johnson Tory P, Trout Amanda L, Hauser Kurt F, Haughey Norman J

Abstract excerpt

The widespread use of combinational antiretroviral therapies (cART) in developed countries has changed the course of Human Immunodeficiency Virus (HIV) infection from an almost universally fatal disease to a chronic infection for the majority of individuals. Although cART has reduced the severity of neurological damage in HIV-infected individuals, the likelihood of cognitive impairment increases with age, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28798382
DOI: 10.1038/s41598-017-07570-5
PMCID: PMC5552766

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