Article
Pathology of borderline HER-2/neu breast carcinoma: a biologically distinct phenotype.
Breast cancer research and treatment - 1 Jul 2006
Killeen Jeffrey L, Ortega-Lopez Anna, Shaha James, Shaha Steven H, Fu Jennifer B
Abstract excerpt
PURPOSE: The significance of HER-2/neu results obtained by immunohistochemical analyses (IHC) which are neither negative nor strongly positive is controversial. The incidence of fluorescence in situ hybridization (FISH) positivity in these tumors is small and the implication is that these borderl...
Topics
- Adult
- Age Factors
- Aged
- Aged, 80 and over
- Breast Neoplasms
- Carcinoma
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Immunohistochemistry
- In Situ Hybridization, Fluorescence
- Middle Aged
- Phenotype
- Receptor, ErbB-2