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Unusual Patterns of HER2 Expression in Breast Cancer: Insights and Perspectives

1 Jan 2022

Abstract excerpt

The biomarker human epidermal growth factor receptor-2 (HER2) has represented the best example of successful targeted therapy in breast cancer patients. Based on the concept of "oncogene addiction," we have learnt how to identify patients likely benefitting from anti-HER2 agents. Since HER2 gene amplification leads to marked overexpression of the HER2 receptors on the cell membrane, immunohistochemistry with...

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PMID: 35500561
DOI: 10.1159/000524227

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