Article
Genotype-activity relationship for Mn-superoxide dismutase, glutathione peroxidase 1 and catalase in humans.
Pharmacogenetics and genomics - 1 Apr 2006
Bastaki Maria, Huen Karen, Manzanillo Paolo, Chande Neha, Chen Connie, Balmes John R, Tager Ira B, Holland Nina
Abstract excerpt
OBJECTIVES: This study examined the association between genetic polymorphisms and enzyme activity for antioxidant enzymes that share a common detoxification pathway: manganese superoxide dismutase (MnSOD), glutathione peroxidase-1 (GPX1) and catalase. METHODS: MnSOD, GPX1, and catalase activities were measured in isolated erythrocytes of 231 healthy, non-smoking student volunteers (55% women, ages 17-21, majority...
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