Article
Associations between catalase phenotype and genotype: modification by epidemiologic factors.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jun 2006
Ahn Jiyoung, Nowell Susan, McCann Susan E, Yu Jihnhee, Carter Lisa, Lang Nicholas P, Kadlubar Fred F, Ratnasinghe Luke D, Ambrosone Christine B
Abstract excerpt
Catalase is an endogenous antioxidant enzyme that neutralizes hydrogen peroxide and is induced by oxidative challenge. A -262C --> T polymorphism in the promoter region of the gene (CAT) is associated with risk of several conditions related to oxidative stress. We sought to determine the functional effects of the CAT polymorphism on enzyme activity in erythrocytes and the potential modifying effects of...
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