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Article

Differential impact of high and low penetrance TNFRSF1A gene mutations on conventional and regulatory CD4+ T cell functions in TNFR1-associated periodic syndrome.

Journal of leukocyte biology - 1 May 2016

Pucino Valentina, Lucherini Orso Maria, Perna Francesco, Obici Laura, Merlini Giampaolo, Cattalini Marco, La Torre Francesco, Maggio Maria Cristina, Lepore Maria Teresa, Magnotti Flora, Galgani Mario, Galeazzi Mauro, Marone Gianni, De Rosa Veronica, Talarico Rosaria, Cantarini Luca, Matarese Giuseppe

Abstract excerpt

TNFR-associated periodic syndrome is an autoinflammatory disorder caused by autosomal-dominant mutations in TNFRSF1A, the gene encoding for TNFR superfamily 1A. The lack of knowledge in the field of TNFR-associated periodic syndrome biology is clear, particularly in the context of control of immune self-tolerance. We investigated how TNF-α/TNFR superfamily 1A signaling can affect T cell biology, focusing on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Antigen, T-Cell

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Identifiers

PMID: 26598380
DOI: 10.1189/jlb.3A0915-399R

Genes

STAT1
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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