Article
The broad spectrum of autoimmune lymphoproliferative disease: molecular bases, clinical features and long-term follow-up in 31 patients.
Haematologica - 1 Apr 2006
Campagnoli Maria Francesca, Garbarini Letizia, Quarello Paola, Garelli Emanuela, Carando Adriana, Baravalle Valentina, Doria Alessandra, Biava Alessandra, Chiocchetti Annalisa, Rosolen Angelo, Dufour Carlo, Dianzani Umberto, Ramenghi Ugo
Abstract excerpt
Autoimmune lymphoproliferative disorders, including autoimmune lymphoproliferative syndrome (ALPS) and Dianzani autoimmune lymphoproliferative disease (DALD), are inherited defects of the Fas apoptotic pathway characterized by lymphoid accumulation and autoimmune manifestations. We report the molecular, clinical, immunologic features and the long-term progress of 31 patients. Four carried Fas gene mutations and...
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