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Article

The clinical spectrum in a large kindred with autoimmune lymphoproliferative syndrome caused by a Fas mutation that impairs lymphocyte apoptosis.

The Journal of pediatrics - 1 Nov 1998

Infante A J, Britton H A, DeNapoli T, Middelton L A, Lenardo M J, Jackson C E, Wang J, Fleisher T, Straus S E, Puck J M

Abstract excerpt

Autoimmune lymphoproliferative syndrome (ALPS) is characterized by chronic, histologically benign splenomegaly and generalized lymphadenopathy, hypergammaglobulinemia, and autoantibody formation. ALPS has been attributed to defective programmed cell death of lymphocytes, most often arising as a result of mutations in the gene encoding the lymphocyte apoptosis receptor Fas/APO-l/CD95. We identified a novel...

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PMID: 9821419
DOI: 10.1016/s0022-3476(98)70102-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The clinical spectrum in a large kindred with autoimmune lymphoproliferative syndrome caused by a Fas mutation that impairs lymphocyte apoptosis.PMID 9821419Read ↗

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A genetic disorder of lymphocyte apoptosis involving the fas pathway: the autoimmune lymphoproliferative syndrome.Semantic proximity Read ↗

An inherited disorder of lymphocyte apoptosis: the autoimmune lymphoproliferative syndrome.Semantic proximity Read ↗

The Autoimmune Lymphoproliferative Syndrome with Defective FAS or FAS-Ligand Functions.Semantic proximity Read ↗

Immunologic evaluation and genetic defects of apoptosis in patients with autoimmune lymphoproliferative syndrome (ALPS).Semantic proximity Read ↗

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Autoimmune Lymphoproliferative Syndrome (ALPS)Semantic proximity Read ↗

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