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Article

A protein sequence that can encode native structure by disfavoring alternate conformations.

Nature structural biology - 1 May 2002

Wigley W Christian, Corboy Michael J, Cutler Todd D, Thibodeau Patrick H, Oldan Jorge, Lee Min Goo, Rizo Josep, Hunt John F, Thomas Philip J

Abstract excerpt

The linear sequence of amino acids contains all the necessary information for a protein to fold into its unique three-dimensional structure. Native protein sequences are known to accomplish this by promoting the formation of stable, kinetically accessible structures. Here we describe a Pro residue in the center of the third transmembrane helix of the cystic fibrosis transmembrane conductance regulator that...

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PMID: 11938353
DOI: 10.1038/nsb784

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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