Article
Bevacizumab-induced transient remodeling of the vasculature in neuroblastoma xenografts results in improved delivery and efficacy of systemically administered chemotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2007
Dickson Paxton V, Hamner John B, Sims Thomas L, Fraga Charles H, Ng Catherine Y C, Rajasekeran Surender, Hagedorn Nikolaus L, McCarville M Beth, Stewart Clinton F, Davidoff Andrew M
Abstract excerpt
PURPOSE: Dysfunctional tumor vessels can be a significant barrier to effective cancer therapy. However, increasing evidence suggests that vascular endothelial growth factor (VEGF) inhibition can effect transient "normalization" of the tumor vasculature, thereby improving tumor perfusion and, consequently, delivery of systemic chemotherapy. We sought to examine temporal changes in tumor vascular function in...
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