Article

Targeting hypoxic habitats with hypoxia pro-drug evofosfamide in preclinical models of sarcoma

2020-10-07

Abstract excerpt

Hypoxic regions (habitats) within tumors are heterogeneously distributed and can be widely variant. Hypoxic habitats are generally pan-therapy resistant. For this reason, hypoxia-activated prodrugs (HAPs) have been developed to target these resistant volumes. The HAP evofosfamide (TH-302) has shown promise in preclinical and early clinical trials of sarcoma. However, in a phase III clinical trial, TH-302 did not i...

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Literature Corpus work: 6cc6c05c-887e-517b-9654-3c2117632b8b
DOI: 10.1101/2020.10.06.326934

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