Article
The human transient receptor potential vanilloid 3 channel is sensitized via the ERK pathway.
The Journal of biological chemistry - 22 Dec 2017
Vyklicka Lenka, Boukalova Stepana, Macikova Lucie, Chvojka Stepan, Vlachova Viktorie
Abstract excerpt
The transient receptor potential vanilloid 3 (TRPV3) channel is a Ca2+-permeable thermosensitive ion channel widely expressed in keratinocytes, where together with epidermal growth factor receptor (EGFR) forms a signaling complex regulating epidermal homeostasis. Proper signaling through this complex is achieved and maintained via several pathways in which TRPV3 activation is absolutely required. Results of...
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