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Article

Immunostimulatory DNA Sequences Necessary for Effective Intradermal Gene Immunization

19 Jul 1996

Abstract excerpt

Vaccination with naked DNA elicits cellular and humoral immune responses that have a T helper cell type 1 bias. However, plasmid vectors expressing large amounts of gene product do not necessarily induce immune responses to the encoded antigens. Instead, the immunogenicity of plasmid DNA (pDNA) requires short immunostimulatory DNA sequences (ISS) that contain a CpG dinucleotide in a particular base context. Human...

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PMID: 8662521
DOI: 10.1126/science.273.5273.352

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