Article
A consensus adenine at position -11 of the nontemplate strand of bacterial promoter is important for nucleation of promoter melting.
The Journal of biological chemistry - 5 May 2006
Heyduk Ewa, Kuznedelov Konstantin, Severinov Konstantin, Heyduk Tomasz
Abstract excerpt
Numerous studies have suggested an important role of adenine at position -11 of the nontemplate strand of bacterial promoters for sequence-specific recognition of the -10 promoter element in single-stranded form. In this work, we attempted to identify a specific step in transcription initiation reaction that is most critically dependent on specific recognition of -11A. Mutating -11A in the context of a model...
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