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Heterogeneity of neoplastic cells in B-cell chronic lymphoproliferative disorders: biclonality versus intraclonal evolution of a single tumor cell clone.

Haematologica - 1 Mar 2006

Sanchez Maria Luz, Almeida Julia, Lopez Antonio, Sayagues Jose Maria, Rasillo Ana, Sarasquete Eugenia A, Balanzategui Ana, Tabernero Maria Dolores, Diaz-Mediavilla Joaquin, Barrachina Carmen, Paiva Artur, Gonzalez Marcos, San Miguel Jesus F, Orfao Alberto

Abstract excerpt

BACKGROUND AND OBJECTIVES: B-cell chronic lymphoproliferative disorders (B-CLPD) are usually monoclonal expansions of a single B-cell clone. However in some cases, two unrelated B-cell clones co-exist. Additionally, cases with two B-cell subpopulations displaying a similar phenotype but distinct DNA contents exist, the exact nature of these cases remaining unknown. In order to gain insight into the...

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PMID: 16531256

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