Article
Biclonal lymphoproliferative disorders: another association with NOTCH1-mutated chronic lymphocytic leukaemias.
Irish journal of medical science - 1 Aug 2021
Fogarty Helen, Dowling Anita, O'Brien David, Langabeer Steve, Bacon Christopher Laurence, Flavin Richard, O'Dwyer Michael, Hennessy Brian, O'Leary Hilary, Crotty Gerard, Henderson Robert, Nolan James, Thornton Patrick, Vandenberghe Elisabeth, Quinn Fiona
Abstract excerpt
INTRODUCTION: Biclonal lymphoid disorders, when two distinct lymphoproliferative disorders (LPD) co-exist, are rare (incidence of 1.4%) and associated with a poor prognosis. NOTCH1 mutations occur in 10% of CLL at diagnosis, associated with a short disease-free interval and increased risk of Richter's transformation. We hypothesised that the incidence of NOTCH1 mutations in CLL with a second LPD may be increased,...
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