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Article

Epigenetic inactivation of the CIP/KIP cell-cycle control pathway in acute leukemias.

American journal of hematology - 1 Dec 2005

Chim C S, Wong A S Y, Kwong Y L

Abstract excerpt

Dysregulation of the cell cycle is important in oncogenesis. We analyzed the potential inactivation of the CIP/KIP family of the cyclin E/CDK/RB pathway by gene promoter hypermethylation in leukemias. The methylation-specific polymerase chain reaction (MSP) with primers for methylated (M-MSP) and unmethylated (U-MSP) alleles of the p21, p27, and p57 genes was used to study five leukemic cell lines, 50 acute...

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Share to Calcium-Binding Proteins
Share to Cell Cycle
Share to Cyclin-Dependent Kinase Inhibitor Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Epigenesis, Genetic

Share to Gene Expression Regulation, Leukemic

Share to Leukemia, Myeloid, Acute

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Source

Identifiers

PMID: 16315255
DOI: 10.1002/ajh.20503

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Epigenetic inactivation of the CIP/KIP cell-cycle control pathway in acute leukemias.PMID 16315255Read ↗

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