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Article

The human DNA polymerase lambda interacts with PCNA through a domain important for DNA primer binding and the interaction is inhibited by p21/WAF1/CIP1.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 2004

Maga Giovanni, Blanca Giuseppina, Shevelev Igor, Frouin Isabelle, Ramadan Kristijan, Spadari Silvio, Villani Giuseppe, Hübscher Ulrich

Abstract excerpt

In this paper we show that DNA polymerase lambda (pol lambda) interacts with proliferating cell nuclear antigen (PCNA) in vivo in human cells. Moreover, by using recombinant mutated PCNA, we could demonstrate that pol lambda interacts with both the interdomain-connecting loop and the nearby hydrophobic pocket on the anterior of PCNA and that critical residues within a helix-hairpin-helix domain of pol lambda,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p21

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Source

Identifiers

PMID: 15358682
DOI: 10.1096/fj.04-2268fje

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The human DNA polymerase lambda interacts with PCNA through a domain important for DNA primer binding and the interaction is inhibited by p21/WAF1/CIP1.PMID 15358682Read ↗

DNA polymerase lambda directly binds to proliferating cell nuclear antigen through its confined C-terminal region.Semantic proximity Read ↗

Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta.Semantic proximity Read ↗

Functional sites of human PCNA which interact with p21 (Cip1/Waf1), DNA polymerase delta and replication factor C.Semantic proximity Read ↗

p21 contains independent binding sites for cyclin and cdk2: both sites are required to inhibit cdk2 kinase activity.Semantic proximity Read ↗

Different types of interaction between PCNA and PIP boxes contribute to distinct cellular functions of Y-family DNA polymerases.Semantic proximity Read ↗

Identification of PCNA interacting protein motifs in human DNA polymerase deltaSemantic proximity Read ↗

Cloning of two rat PDIP1 related genes and their interactions with proliferating cell nuclear antigenSemantic proximity Read ↗

Human replication protein A can suppress the intrinsic in vitro mutator phenotype of human DNA polymerase lambda.Semantic proximity Read ↗

p53 and p21 regulate error-prone DNA repair to yield a lower mutation load.Semantic proximity Read ↗

Direct Interaction of Proliferating Cell Nuclear Antigen with the Small Subunit of DNA Polymerase δSemantic proximity Read ↗

Identification of two functional PCNA-binding domains in human DNA polymerase κ.Semantic proximity Read ↗

Structure of proliferating cell nuclear antigen (PCNA) bound to an APIM peptide reveals the universality of PCNA interaction.Semantic proximity Read ↗

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