Article
Oncogenic Met receptor induces ectopic structures in Xenopus embryos.
Oncogene - 20 Jul 2006
Ishimura A, Lee H-S, Bong Y-S, Saucier C, Mood K, Park E K, Daar I O
Abstract excerpt
When aberrantly expressed or activated, the Met receptor tyrosine kinase is involved in tumor invasiveness and metastasis. In this study, we have used the Xenopus embryonic system to define the role of various Met proximal-binding partners and downstream signaling pathways in regulating an induced morphogenetic event. We show that expression of an oncogenic derivative of the Met receptor (Tpr-Met) induces ectopic...
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