Article
Overexpression of cellular prion protein induces an antioxidant environment altering T cell development in the thymus.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2006
Jouvin-Marche Evelyne, Attuil-Audenis Valérie, Aude-Garcia Catherine, Rachidi Walid, Zabel Mark, Podevin-Dimster Valérie, Siret Carole, Huber Christoph, Martinic Marianne, Riondel Jacqueline, Villiers Christian L, Favier Alain, Naquet Philippe, Cesbron Jean-Yves, Marche Patrice N
Abstract excerpt
Cellular prion protein (PrP(C)) is an ubiquitously expressed glycoprotein whose roles are still widely discussed, particularly in the field of immunology. Using TgA20- and Tg33-transgenic mice overexpressing PrP(C), we investigated the consequences of this overexpression on T cell development. In both models, overexpression of PrP(C) induces strong alterations at different steps of T cell maturation. On TgA20...
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