Article
Regulatory T cells can mediate their function through the stimulation of APCs to produce immunosuppressive nitric oxide.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2006
Chen Cyndi, Lee Wen-hui, Zhong Lingwen, Liu Chih-Pin
Abstract excerpt
Regulatory T cells (Tr cells) play a critical role in inducing immune tolerance. It remains largely unclear how various types of Tr cells perform their regulatory function. We have studied the underlying regulatory mechanism of a population of autoantigen-specific CD4+ Tr cells. These T cells are specific for the glutamic acid decarboxylase p206-220 peptide and are isolated from the diabetes-resistant...
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