Article
Alternate transcription of the Toll-like receptor signaling cascade.
Genome biology - 1 Jan 2006
Wells Christine A, Chalk Alistair M, Forrest Alistair, Taylor Darrin, Waddell Nic, Schroder Kate, Himes S Roy, Faulkner Geoffrey, Lo Sandra, Kasukawa Takeya, Kawaji Hideya, Kai Chikatoshi, Kawai Jun, Katayama Shintaro, Carninci Piero, Hayashizaki Yoshihide, Hume David A, Grimmond Sean M
Abstract excerpt
BACKGROUND: Alternate splicing of key signaling molecules in the Toll-like receptor (Tlr) cascade has been shown to dramatically alter the signaling capacity of inflammatory cells, but it is not known how common this mechanism is. We provide transcriptional evidence of widespread alternate splicing in the Toll-like receptor signaling pathway, derived from a systematic analysis of the FANTOM3 mouse data set....
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