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Article

Transcriptome-Wide Analysis Reveals Modulation of Human Macrophage Inflammatory Phenotype Through Alternative Splicing.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2016

Lin Jennie, Hu Yu, Nunez Sara, Foulkes Andrea S, Cieply Benjamin, Xue Chenyi, Gerelus Mark, Li Wenjun, Zhang Hanrui, Rader Daniel J, Musunuru Kiran, Li Mingyao, Reilly Muredach P

Abstract excerpt

OBJECTIVE: Human macrophages can shift phenotype across the inflammatory M1 and reparative M2 spectrum in response to environmental challenges, but the mechanisms promoting inflammatory and cardiometabolic disease-associated M1 phenotypes remain incompletely understood. Alternative splicing (AS) is emerging as an important regulator of cellular function, yet its role in macrophage activation is largely unknown....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27230130
DOI: 10.1161/ATVBAHA.116.307573
PMCID: PMC4919157

Genes

CELF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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