Article
Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages.
Proceedings of the National Academy of Sciences of the United States of America - 17 Apr 2012
Schroder Kate, Irvine Katharine M, Taylor Martin S, Bokil Nilesh J, Le Cao Kim-Anh, Masterman Kelly-Anne, Labzin Larisa I, Semple Colin A, Kapetanovic Ronan, Fairbairn Lynsey, Akalin Altuna, Faulkner Geoffrey J, Baillie John Kenneth, Gongora Milena, Daub Carsten O, Kawaji Hideya, McLachlan Geoffrey J, Goldman Nick, Grimmond Sean M, Carninci Piero, Suzuki Harukazu, Hayashizaki Yoshihide, Lenhard Boris, Hume David A, Sweet Matthew J
Abstract excerpt
Evolutionary change in gene expression is generally considered to be a major driver of phenotypic differences between species. We investigated innate immune diversification by analyzing interspecies differences in the transcriptional responses of primary human and mouse macrophages to the Toll-like receptor (TLR)-4 agonist lipopolysaccharide (LPS). By using a custom platform permitting cross-species interrogation...
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