Article
No evidence for an association between the -871 T/C promoter polymorphism in the B-cell-activating factor gene and primary Sjögren's syndrome.
Arthritis research & therapy - 1 Jan 2006
Gottenberg Jacques-Eric, Sellam Jérémie, Ittah Marc, Lavie Frédéric, Proust Alexis, Zouali Habib, Sordet Christelle, Sibilia Jean, Kimberly Robert P, Mariette Xavier, Miceli-Richard Corinne
Abstract excerpt
Polyclonal B cell activation might be related to pathogenic over-expression of B-cell-activating factor (BAFF) in primary Sjögren's syndrome (pSS) and other autoimmune diseases. We therefore investigated whether BAFF over-expression in pSS could be a primary, genetically determined event that leads to the disease. The complete BAFF gene was sequenced in Caucasian pSS patients and control individuals. The only...
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