Article
Fas gene promoter polymorphisms in primary Sjögren's syndrome.
Annals of the rheumatic diseases - 1 Jan 2004
Mullighan C G, Heatley S, Lester S, Rischmueller M, Gordon T P, Bardy P G
Abstract excerpt
BACKGROUND: Fas mediated apoptosis may be important in the pathogenesis of primary Sjögren's syndrome (pSS). OBJECTIVE: To examine genetic variation in the promoter region of the Fas gene in pSS. METHODS: Two single nucleotide polymorphisms at positions -1377(G/A) and -670(G/A) in the Fas gene promoter were genotyped by PCR-SSP in 101 patients with pSS and 108 Caucasoid controls. RESULTS: No significant...
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