Article
Polymorphisms of the promoter and exon 3 of the receptor for advanced glycation end products (RAGE) in Euro- and Afro-Brazilians.
International journal of immunogenetics - 1 Apr 2012
Torres M C, Beltrame M H, Santos I C R, Picheth G, Petzl-Erler M L, Pedrosa F O, Steffens M B R, de Souza E M
Abstract excerpt
The receptor for advanced glycation end products (RAGE or AGER), a member of the immunoglobulin superfamily, is involved in pathologies such as atherosclerosis and diabetes. Over 50 SNPs were reported for RAGE, among which were the promoter region polymorphisms -429T>C (rs1800625), -374T>A (rs1800624) and a 63-bp deletion (-407 to -345 bp), all related to increased RAGE expression. Additionally, in the exon 3, a...
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