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Article

Structural basis of the stereospecificity of bacterial B12-dependent 2-hydroxyisobutyryl-CoA mutase.

The Journal of biological chemistry - 10 Apr 2015

Kurteva-Yaneva Nadya, Zahn Michael, Weichler M-Teresa, Starke Robert, Harms Hauke, Müller Roland H, Sträter Norbert, Rohwerder Thore

Abstract excerpt

Bacterial coenzyme B12-dependent 2-hydroxyisobutyryl-CoA mutase (HCM) is a radical enzyme catalyzing the stereospecific interconversion of (S)-3-hydroxybutyryl- and 2-hydroxyisobutyryl-CoA. It consists of two subunits, HcmA and HcmB. To characterize the determinants of substrate specificity, we h...

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Identifiers

PMID: 25720495
DOI: 10.1074/jbc.M115.645689
PMCID: PMC4392272

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25720495-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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