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Article

Bacterial acyl-CoA mutase specifically catalyzes coenzyme B12-dependent isomerization of 2-hydroxyisobutyryl-CoA and (S)-3-hydroxybutyryl-CoA.

The Journal of biological chemistry - 4 May 2012

Yaneva Nadya, Schuster Judith, Schäfer Franziska, Lede Vera, Przybylski Denise, Paproth Torsten, Harms Hauke, Müller Roland H, Rohwerder Thore

Abstract excerpt

Coenzyme B(12)-dependent acyl-CoA mutases are radical enzymes catalyzing reversible carbon skeleton rearrangements in carboxylic acids. Here, we describe 2-hydroxyisobutyryl-CoA mutase (HCM) found in the bacterium Aquincola tertiaricarbonis as a novel member of the mutase family. HCM specifically catalyzes the interconversion of 2-hydroxyisobutyryl- and (S)-3-hydroxybutyryl-CoA. Like isobutyryl-CoA mutase, HCM...

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Identifiers

PMID: 22433853
DOI: 10.1074/jbc.M111.314690
PMCID: PMC3346121

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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