Article
Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and Rel proteins.
Molecular and cellular biology - 1 Aug 1997
Plevy S E, Gemberling J H, Hsu S, Dorner A J, Smale S T
Abstract excerpt
Interleukin 12 (IL-12) is a heterodimeric cytokine whose activity is critical for T-helper 1 responses. The gene for the IL-12 p40 subunit is expressed in macrophages following induction by bacterial products, and its expression is augmented by gamma interferon. In this study, we performed a func...
Topics
- Animals
- Base Sequence
- Binding Sites
- CCAAT-Enhancer-Binding Protein-beta
- CCAAT-Enhancer-Binding Proteins
- Cell Line
- Cycloheximide
- DNA Footprinting
- DNA-Binding Proteins
- Humans
- Interferon-gamma
- Interleukin-12
- Lipopolysaccharides
- Listeria monocytogenes
- Macrophages