Article
Expression of perforin in infiltrating cells in murine hearts with acute myocarditis caused by coxsackievirus B3.
Circulation - 1 Aug 1991
Seko Y, Shinkai Y, Kawasaki A, Yagita H, Okumura K, Takaku F, Yazaki Y
Abstract excerpt
BACKGROUND: Cell-mediated autoimmunity has been strongly implicated in the pathogenesis of viral myocarditis. METHODS AND RESULTS: Using a murine model of acute myocarditis caused by coxsackievirus B3, we analyzed the phenotypes and morphology of the infiltrating cells in the hearts by immunofluo...
Topics
- Acute Disease
- Animals
- Coxsackievirus Infections
- Enterovirus B, Human
- Fluorescent Antibody Technique
- Membrane Glycoproteins
- Membrane Proteins
- Mice
- Mice, Inbred C3H
- Microscopy, Electron
- Myocarditis
- Myocardium
- Nucleic Acid Hybridization
- Perforin
- Phenotype
- Pore Forming Cytotoxic Proteins
- RNA, Messenger
- T-Lymphocytes, Cytotoxic