Article
Two distinct but interchangeable mechanisms for flipping of lipid-linked oligosaccharides.
The EMBO journal - 8 Mar 2006
Alaimo Cristina, Catrein Ina, Morf Laura, Marolda Cristina L, Callewaert Nico, Valvano Miguel A, Feldman Mario F, Aebi Markus
Abstract excerpt
Translocation of lipid-linked oligosaccharide (LLO) intermediates across membranes is an essential but poorly understood process in eukaryotic and bacterial glycosylation pathways. Membrane proteins defined as translocases or flippases are implicated to mediate the translocation reaction. The membrane protein Wzx has been proposed to mediate the translocation across the plasma membrane of lipopolysaccharide (LPS)...
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