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Article

Vitamin C controls the cystic fibrosis transmembrane conductance regulator chloride channel.

Proceedings of the National Academy of Sciences of the United States of America - 9 Mar 2004

Fischer Horst, Schwarzer Christian, Illek Beate

Abstract excerpt

Vitamin C (l-ascorbate) is present in the respiratory lining fluid of human lungs, and local deficits occur during oxidative stress. Here we report a unique function of vitamin C on the cystic fibrosis (CF) transmembrane conductance regulator (CFTR), a cAMP-dependent Cl channel that regulates epithelial surface fluid secretion. Vitamin C (100 microM) induced the openings of CFTR Cl channels by increasing its...

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Source

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Identifiers

PMID: 14993613
DOI: 10.1073/pnas.0308393100
PMCID: PMC373524

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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