Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

B cell phenotypes in baboons with pig artery patch grafts receiving conventional immunosuppressive therapy.

Transplant immunology - 1 Dec 2018

Yamamoto Takayuki, Li Qi, Hara Hidetaka, Wang Liaoran, Zhou Hongmin, Li Juan, Eckhoff Devin E, Joseph Tector A, Klein Edwin C, Lovingood Ray, Ezzelarab Mohamed, Ayares David, Wang Yi, Cooper David K C, Iwase Hayato

Abstract excerpt

BACKGROUND: In the pig-to-baboon artery patch model with no immunosuppressive therapy, a graft from an α1,3-galactosyltransferase gene-knockout (GTKO) pig elicits a significant anti-nonGal IgG response, indicating sensitization to the graft. A costimulation blockade-based regimen, e.g., anti-CD154mAb or anti-CD40mAb, prevents sensitization. However, neither of these agents is currently FDA-approved. The aim of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Abatacept
Share to Adaptive Immunity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Arteries

Share to Drug Approval

Share to Galactosyltransferases

Share to Sirolimus

Share to Tacrolimus

Source

Open in PubMed Open full text

Identifiers

PMID: 30092338
DOI: 10.1016/j.trim.2018.08.005
PMCID: PMC6249078

Genes

CTLA4
CIITA
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

B cell phenotypes in baboons with pig artery patch grafts receiving conventional immunosuppressive therapy.PMID 30092338Read ↗

Immunological and physiological observations in baboons with life‐supporting genetically engineered pig kidney graftsSemantic proximity Read ↗

Elicited antibodies in baboons exposed to tissues from alpha1,3-galactosyltransferase gene-knockout pigs.Semantic proximity Read ↗

Prolonged xenokidney graft survival in sensitized NHP recipients by expression of multiple human transgenes in a triple knockout pigSemantic proximity Read ↗

Thrombotic Microangiopathy Associated with Humoral Rejection of Cardiac Xenografts from α1,3-Galactosyltransferase Gene-Knockout Pigs in BaboonsSemantic proximity Read ↗

α1,3-Galactosyltransferase Gene-Knockout Pigs for Xenotransplantation: Where Do We Go From Here?Semantic proximity Read ↗

Production of Triple-Gene (GGTA1, B2M and CIITA)-Modified Donor Pigs for XenotransplantationSemantic proximity Read ↗

Generation of GGTA1−/−β2M−/−CIITA−/− Pigs Using CRISPR/Cas9 Technology to Alleviate Xenogeneic Immune ReactionsSemantic proximity Read ↗

A HUMAN CD46 TRANSGENIC PIG MODEL SYSTEM FOR THE STUDY OF DISCORDANT XENOTRANSPLANTATIONSemantic proximity Read ↗

The potential of genetically-engineered pigs in providing an alternative source of organs and cells for transplantationSemantic proximity Read ↗

HLA-G1+ Expression in GGTA1KO Pigs Suppresses Human and Monkey Anti-Pig T, B and NK Cell Responses.Semantic proximity Read ↗

Kidney xenotransplantation.Semantic proximity Read ↗

Hepatic Function After Genetically Engineered Pig Liver Transplantation in BaboonsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.