Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Movement disorders in the Hfe knockout mouse.

Nutritional neuroscience - 1 Aug 2005

Golub Mari S, Germann Stacey L, Araiza Renee S, Reader J Rachel, Griffey Stephen M, Lloyd K C Kent

Abstract excerpt

The Hfe(- /-) mouse is a model for human hereditary hemochromatosis (HHH). The accumulation of tissue iron in this condition has led to the suggestion that HHH patients may be at higher risk for neurodegenerative diseases. In this study, adult male Hfe(-/-) mice and wildtype controls (n = 12/group) were evaluated for impairment with motor tests (stride length, landing footsplay, rotarod) as well as a general...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Hemochromatosis
Share to Hemochromatosis Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histocompatibility Antigens Class I

Share to Membrane Proteins

Share to Mice, Knockout

Share to Motor Activity

Share to Movement Disorders

Source

Identifiers

PMID: 16491649
DOI: 10.1080/10284150500277685

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Movement disorders in the Hfe knockout mouse.PMID 16491649Read ↗

A mouse model of hemochromatosis-related mutations with brain iron dyshomeostasis exhibits loss of tyrosine hydroxylase expression in dopaminergic neurons and motor control impairment relevant to Parkinson’s diseaseSemantic proximity Read ↗

Behavioral characterization of mouse models of neuroferritinopathy.Semantic proximity Read ↗

HFE gene knockout produces mouse model of hereditary hemochromatosisSemantic proximity Read ↗

Movement Disorders Associated With Hemochromatosis.Semantic proximity Read ↗

Bone status in a mouse model of genetic hemochromatosis.Semantic proximity Read ↗

Animal models of RLS phenotypes.Semantic proximity Read ↗

Systemic and Cerebral Iron Homeostasis in Ferritin Knock-Out MiceSemantic proximity Read ↗

Bone Morphogenetic Protein Signaling Is Impaired in an Hfe Knockout Mouse Model of HemochromatosisSemantic proximity Read ↗

Contribution of the H63D mutation in HFE to murine hereditary hemochromatosis.Semantic proximity Read ↗

A Longitudinal Motor Characterisation of the HdhQ111 Mouse Model of Huntington's Disease.Semantic proximity Read ↗

Mouse strain differences determine severity of iron accumulation in <i>Hfe</i> knockout model of hereditary hemochromatosisSemantic proximity Read ↗

Haptoglobin modifies the hemochromatosis phenotype in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.