Article
PRKAR1A in the development of cardiac myxoma: a study of 110 cases including isolated and syndromic tumors.
The American journal of surgical pathology - 1 Aug 2014
Maleszewski Joseph J, Larsen Brandon T, Kip Nefize Sertac, Castonguay Mathieu C, Edwards William D, Carney J Aidan, Kipp Benjamin R
Abstract excerpt
Cardiac myxoma usually occurs as a solitary mass, but occasionally develops as part of a familial syndrome, the Carney complex (CNC). Two thirds of CNC-associated cardiac myxomas exhibit mutations in PRKAR1A. PRKAR1A mutations occur in both familial and sporadic forms of CNC but have not been described in isolated (nonsyndromic) cardiac myxomas. A total of 127 consecutive cardiac myxomas surgically resected at...
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