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Article

Biochemical basis of partial nephrogenic diabetes insipidus phenotypes.

Molecular endocrinology (Baltimore, Md.) - 1 Nov 1997

Sadeghi H, Robertson G L, Bichet D G, Innamorati G, Birnbaumer M

Abstract excerpt

Biochemical properties of mutant type 2 vasopressin receptors (V2Rs) causing a partial phenotype of nephrogenic diabetes insipidus were investigated in transiently transfected HEK 293 cells. Cell surface expression of the V2R was not altered by substituting Asp85 in the second transmembrane region by Asn as determined by saturation binding assays. Although the affinity of the mutant V2R for arginine vasopressin...

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Share to Amino Acid Substitution
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Share to Diabetes Insipidus, Nephrogenic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Receptors, Vasopressin

Source

Identifiers

PMID: 9369448
DOI: 10.1210/mend.11.12.0017

Genes

AVP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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