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Article

Divergent GABA(A) receptor-mediated synaptic transmission in genetically seizure-prone and seizure-resistant rats.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Nov 2002

McIntyre Dan C, Hutcheon Bruce, Schwabe Kerstin, Poulter Michael O

Abstract excerpt

Recent evidence suggests that abnormal expression of GABA(A) receptors may underlie epileptogenesis. We observed previously that rats selectively bred to be seizure-prone naturally overexpressed, as adults, GABA alpha subunits (alpha2, alpha3, and alpha5) seen at birth, whereas those selected to be seizure-resistant overexpressed the adult, alpha1 subunit. In this experiment, we gathered GABA miniature IPSCs...

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Identifiers

PMID: 12427849
PMCID: PMC6757834

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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