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Article

Biological evaluation of tubulysin A: a potential anticancer and antiangiogenic natural product

15 May 2006

Abstract excerpt

Tubulysin A (tubA) is a natural product isolated from a strain of myxobacteria that has been shown to depolymerize microtubules and induce mitotic arrest. The potential of tubA as an anticancer and antiangiogenic agent is explored in the present study. tubA shows potent antiproliferative activity in a panel of human cancer cell lines irrespective of their multidrug resistance properties. It induces apoptosis in...

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PMID: 16489930
DOI: 10.1042/bj20051735

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