Article
Synthesis and structure-activity relationship studies of novel tubulysin U analogues--effect on cytotoxicity of structural variations in the tubuvaline fragment.
Organic & biomolecular chemistry - 14 Apr 2013
Shankar Sreejith P, Jagodzinska Monika, Malpezzi Luciana, Lazzari Paolo, Manca Ilaria, Greig Iain R, Sani Monica, Zanda Matteo
Abstract excerpt
Tubulysins are cytotoxic natural products with promising anti-cancer properties, originally isolated from myxobacterial cultures. Structurally, tubulysins are tetrapeptides, incorporating three unusual (Mep, Tuv and Tup) and one proteinogenic amino acid (Ile). Here we describe the synthesis and structure-activity relationship studies of novel tubulysin U and V analogues, with variations in the central Tuv...
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