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Article

Variant diphtheria toxin-interleukin-3 fusion proteins with increased receptor affinity have enhanced cytotoxicity against acute myeloid leukemia progenitors.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Feb 2006

Hogge Donna E, Yalcintepe Leman, Wong Siaw-Hui, Gerhard Brigitte, Frankel Arthur E

Abstract excerpt

A fusion protein linking a truncated form of diphtheria toxin (DT(388)) to human interleukin-3 (DT(388)IL3) kills malignant progenitors from some patients with acute myeloid leukemia (AML) while sparing normal progenitors. This study evaluated two variants of DT(388)IL3 with increased affinity for the IL-3 receptor (IL-3R) for their cytotoxicity to AML progenitors and determined the ability of quantitative...

Topics

Adolescent
Adult
Aged
Cell Survival
Diphtheria Toxin
Dose-Response Relationship, Drug
Female
Gene Expression
Humans
Interleukin-3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukemia, Myeloid, Acute

Male

Middle Aged

Mutation

Neoplastic Stem Cells

Protein Subunits

RNA, Messenger

Receptors, Interleukin-3

Source

Identifiers

PMID: 16489085
DOI: 10.1158/1078-0432.CCR-05-2070

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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