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Article

Characterization of variant diphtheria toxin-interleukin-3 fusion protein, DTIL3K116W, for phase I clinical trials.

Biologicals : journal of the International Association of Biological Standardization - 1 Jan 2010

Su Yunpeng, Li Shi-Yan, Ghosh Sunil, Ortiz Janelle, Hogge Donna E, Frankel Arthur E

Abstract excerpt

We have produced clinical grade of DTIL3K116W, a variant diphtheria toxin-interleukin-3 fusion protein, for treatment of acute myeloid leukemia. The product was filter sterilized, aseptically vialed, and stored at -80 degrees C. It was characterized by Coomassie-stained SDS-PAGE, endotoxin assay, cytotoxicity assay, sterility, mass spectroscopy, receptor binding affinity, ADP-ribosylation, inhibition of normal...

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PMID: 19783458
DOI: 10.1016/j.biologicals.2009.08.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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