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A Prospero-related Homeodomain Protein Is a Novel Co-regulator of Hepatocyte Nuclear Factor 4α That Regulates the Cholesterol 7α-Hydroxylase Gene

17 Feb 2006

Abstract excerpt

Prox1, an early specific marker for developing liver and pancreas in foregut endoderm has recently been shown to interact with alpha-fetoprotein transcription factor and repress cholesterol 7alpha-hydroxylase (CYP7A1) gene transcription. Using a yeast two-hybrid assay, we found that Prox1 strongly and specifically interacted with hepatocyte nuclear factor (HNF)4alpha, an important transactivator of the human...

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PMID: 16488887
DOI: 10.1074/jbc.m513420200

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A Prospero-related Homeodomain Protein Is a Novel Co-regulator of Hepatocyte Nuclear Factor 4α That Regulates the Cholesterol 7α-Hydroxylase GenePMID 16488887Read ↗

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