Article
Mutation-induced fold switching among lattice proteins.
The Journal of chemical physics - 21 Nov 2011
Holzgräfe Christian, Irbäck Anders, Troein Carl
Abstract excerpt
Recent experiments uncovered a mutational pathway between two proteins, along which a single mutation causes a switch in fold. Searching for such paths between real proteins remains, despite this achievement, a true challenge. Here, we analyze fold switching in the minimalistic hydrophobic/polar model on a square lattice. For this analysis, we generate a comprehensive sequence-structure database for chains of...
Topics
- Models, Chemical
- Mutation
- Protein Folding
- Protein Stability
- Proteins
- Thermodynamics