Article
Protein stability promotes evolvability.
Proceedings of the National Academy of Sciences of the United States of America - 11 Apr 2006
Bloom Jesse D, Labthavikul Sy T, Otey Christopher R, Arnold Frances H
Abstract excerpt
The biophysical properties that enable proteins to so readily evolve to perform diverse biochemical tasks are largely unknown. Here, we show that a protein's capacity to evolve is enhanced by the mutational robustness conferred by extra stability. We use simulations with model lattice proteins to demonstrate how extra stability increases evolvability by allowing a protein to accept a wider range of beneficial...
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