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Retigabine and gabapentin restore channel function and neuronal firing of an epilepsy-associated dominant-negative <i>KCNQ5</i> variant

2023-03-25

Abstract excerpt

<h4>Objective</h4> KCNQ5 encodes the voltage-gated potassium channel K V 7.5, a member of the K V 7 channel family, which conducts the M-current. This current was shown to be a potent regulator of neuronal excitability by mediating the medium and slow afterhyperpolarization. Recently, we have identified five loss-of-function variants in KCNQ5 in patients with genetic generalized epilepsy. Using the most severe...

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Identifiers and source

Literature Corpus work
84c007e3-1de7-598d-be33-f0f68975e1ee
DOI
10.1101/2023.03.24.534091
Open publication

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Retigabine and gabapentin restore channel function and neuronal firing of an epilepsy-associated dominant-negative <i>KCNQ5</i> variantDOI 10.1101/2023.03.24.534091
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