Article
Increased response to cholesterol feeding in apolipoprotein C1-deficient mice.
The Biochemical journal - 1 Feb 1995
van Ree J H, Hofker M H, van den Broek W J, van Deursen J M, van der Boom H, Frants R R, Wieringa B, Havekes L M
Abstract excerpt
The function of apolipoprotein (apo) C1 in vivo is not well understood. From in vitro studies it has been reported that an excess of apoC1 relative to apoE inhibits receptor-mediated uptake of remnant lipoproteins [Sehayek and Eisenberg (1991) J. Biol. Chem. 266, 22453-22459]. In order to gain a better understanding of the role of apoC1 in lipoprotein metabolism in vivo, we have generated apoC1-deficient mice by...
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